The Osa Peninsula and Manuel Antonio National Park are approximately 130 miles (209 km) apart. Both locations encompass hundreds of acres of remote wilderness so it's helpful to use the nearby towns of Puerto Jimenez and Quepos for planning purposes. Route 34, also known as Costanera Sur, is the most direct drive.
Private transfer is the easiest and most efficient means of travel. The trip should take three to four hours. Driving the unpaved roads throughout the Peninsula can be tricky so having someone who knows the area well is a huge benefit. You'll also have the most control over your pick-up/drop-off locations and the number of stops you make along the trip.
Bus and taxi are the next best options, especially if used together but be sure to account for extra time. These parts of Costa Rica are quite rural and out of the way so public transit isn't as frequent. If time is of the essence, consider reserving your transportation ahead of time.
By Private Transfer
Duration: 3-4 hours
From Puerto Jimenez, you'll travel north up the coast on Route 245 alongside national parks and wildlife reserves. This section will take the most time as the roads are narrow and winding. Once you reach Route 2, the Inter American Highway, your driver will be much smoother. From there, you'll connect to Route 34 for the rest of the way to Quepos.
Duration: 3-4 hours
For a cheaper option, book a private taxi. If you think you might want to do some exploring, inquire about full-day rates. The town of Puerto Jimenez is a busy ferry terminal so you'll find plenty of taxi stands near the port. Keep in mind, there is also a Colectivo, or shared taxi truck, that operates around the Osa Peninsula but the route is limited.
Duration: 6-7 hours
A direct bus leaves twice daily (morning and afternoon) out of the downtown station. This is a reliable and affordable way to travel but your ride will be considerably longer. Tourist shuttles, though more expensive, are also worth considering. They run more frequently and can usually provide door-to-door service. Check ahead on company websites to get the most up-to-date schedules and prices.