The best way to travel between Ushuaia, gateway to Tierra del Fuego National Park, and El Calafate 545 miles (877 km) away is by plane, a 1.5-hour flight. Renting a car and is technically possible (and takes around 14 hours), though the added hassle of crossing the border several times and returning the car to its point of departure means it is not recommended.
This 12-day trip covers many of Argentina's highlights, including overnights in both Ushuaia and El Calafate.
Duration: 1.5 hours, plus travel to/from airports
The Ushuaia airport is only 4 miles from the city center, and is best accessed by taxi or private transfer. From there you can board a flight to El Calafate, which lasts an hour and a half. Once you arrive in El Calafate, shuttle buses run by Ves Patagonia leave after each incoming flight and can take you to your hotel.
There are also private taxis available, as well as several rental car companies. The city center is only 12 miles away from the airport and takes about 20 minutes to reach.