Ushuaia, the southernmost city in Argentina, and Iguazú Falls, a natural landmark at the country's border with Brazil, are as far away as any two spots in Argentina can be. To get from one extreme to another, you must cross 2,698 miles (4,342 km), and the easiest way to do this is by plane. Most flights include layovers in Buenos Aires, but still shave considerable time off of any other transport option. Though Argentina can be a beautiful country to drive through, this route will take two full days at minimum and includes a ferry ride, so it's not recommended.
This 12-day itinerary covers the best Argentina has to offer, including both Ushuaia and Iguazú Falls. For a more feasible drive from one end of Argentina to another, consider this 16-day self-drive tour from Buenos Aires to El Calafate.
Duration: 6.5 hours, depending on connections
Ushuaia's Malvinas Argentinas Ushuaia International Airport (USH) is just 2.5 miles (4 km) outside of the city center, and you can get there by taxi or private transfer. Both Aerolineas Argentinas and LATAM offer multiple daily flights from Ushuaia to Buenos Aires' Aeroparque (AER) and then on to Cataracas del Iguazú International Airport (IGR). Be sure to avoid flights with transfers between Ezeiza (EZE) and Aeroparque, since there are 23.7 miles (38.2 km) and Buenos Aires traffic between them.
From Iguazú International Airport, a private transfer, taxi, rental car, or shuttle bus can take you the last 6 miles (10 km) into the national park itself.