With 10 days in Spain and Italy, you can check out each country's iconic landmarks and idyllic countrysides on a highlights tour or focus on the picturesque coastlines of the Costa Brava and the Amalfi Coast during a sun-kissed adventure. Foodies will find Naples, Rome, and San Sebastián the perfect places to visit, while active explorers delight in a three-day hike in the Italian Dolomites. Or, for those seeking an off-the-beaten-path experience, grab a rental car and tour lesser-visited villages.

Itinerary #1: Highlights of Italy & Spain

Discover the classic highlights of Italy and Spain on this trip crafted for first-time visitors. Starting in Rome, you'll visit iconic sites like the Pantheon and Colosseum with a guide and detour into the Alban Hills. Continue to Florence for a winery tour through the Chianti Hills before hopping over to Spain to admire Barcelona's famed architecture and Madrid's impressive art collection. With a mix of history, art, cuisine, and rural charm, this itinerary promises a well-rounded introduction to two of Europe's most vibrant countries.

See famous artworks at Madrid's Prado Museum on your last full day
See famous artworks at Madrid's Prado Museum on your last full day
Day Highlights Overnight
Day 1 Arrive in Rome (Italy), Afternoon Food Tour Rome
Day 2 Rome Highlights Tour, Optional Vatican City Visit Rome
Day 3 Day Trip to Castelli Romani & Lake Albano Rome
Day 4 Train to Florence, Highlights Tour & Gelato Workshop Florence
Day 5 Tuscan Wine Tour, Explore San Gimignano Florence
Day 6 Fly to Barcelona (Spain), Evening Tapas Tour Barcelona
Day 7 Gaudí Architecture Tour Barcelona
Day 8 Train to Madrid, Local Market Tour Madrid
Day 9 Madrid History & Art Tour Madrid
Day 10 Depart Madrid  

Welcome to Italy! Your adventure begins in the renowned capital city of Rome. While here, you'll delve into the city's culinary scene during a food tour and visit iconic sites such as the Spanish Steps, Pantheon, and the Colosseum alongside a guide. An optional tour of Vatican City is also on the agenda, followed by a day trip to the wine-producing Castelli Romani region. Next, board a train bound for Florence and soon find yourself walking in the footsteps of da Vinci and Michelangelo during a city tour and being whisked into the countryside for a winery experience in the Chianti Hills.

Midway through your trip, a short flight brings you to Barcelona, Spain, where you'll waste no time refreshing at your hotel and joining a tapas experience through the Gothic Quarter. Spend the following day admiring Antoni Guadí architecture while on a walking tour, then settle in for a relaxing train ride to Madrid. Upon arrival, start your stay by browsing markets dating back to medieval times, including the Mercado de San Miguel and Mercado Ildefonso. Lastly, dedicate a day to the Habsburg district's history, culture, and architecture on a private tour before bidding adiós to Spain. Learn more

Itinerary #2: Culinary Journey Through Italy & Spain

From a Neapolitan pizza masterclass in Naples to pintxos bar hopping in Bilbao, this 10-day trip through Italy and Spain is all about the food. Whether you're an aspiring foodie or love sampling new flavors, this itinerary is the perfect introduction to each country's markets, street food scenes, fine-dining restaurants, and picturesque wineries. You'll also embark on guided tours and independent walks around Naples, Rome, Bilbao, San Sebastián, and Madrid.

Savor authentic cuisine and delicious Spanish wines during your foodie adventure
Savor authentic cuisine and delicious Spanish wines during your foodie adventure
Day Highlights Overnight
Day 1 Arrive in Naples (Italy), Neapolitan Street Food Experience Naples
Day 2 Free Morning, Neapolitan Pizza Masterclass Naples
Day 3 Half-Day Trip to Pompeii Naples
Day 4 Train to Rome, Private Highlights Tour of the Eternal City Rome
Day 5 Pasta & Tiramisú Cooking Class, Visit Frascati, Guided Wine Experience Rome
Day 6 Fly to Bilbao (Spain), Pintxos Gastronomy Experience Bilbao
Day 7 Private Tour of Bilbao, Transfer to San Sebastián, Explore  San Sebastián
Day 8 Full-Day Wine Tasting & Tour of La Rioja San Sebastián
Day 9 Train to Madrid, Explore Spain's Capital City Madrid
Day 10 Wine Tour in Madrid's Countryside, Depart  

Hopefully, you've arrived hungry, as after arriving in Naples, you'll head out on a street food tour through Mercato della Pignasecca and San Gregorio Armeno. Walk up an appetite the next morning while exploring the city independently and delve into the secrets of Neapolitan pizza during a cooking class. The following day features a visit to Pompeii, a once-thriving city buried by volcanic debris, and a delightful dinner of local specialties. Then, whizz to Rome by train and spend two days here admiring prolific Roman ruins, learning to make traditional pasta, and sipping wine in the idyllic town of Frascati

The second leg of your journey begins with a flight to Bilbao, a port city in Spain renowned for its food culture. A one-night stay gives you ample time to join a pintxos (Basque tapas) tour and discover city highlights before transferring to San Sebastián. Spend the evening dining at one of the many pintxos bars, then dedicate the following day to sipping wine in the picturesque La Rioja region. Of course, Madrid is a must-visit on any food-focused trip, so you'll round off your adventure by roaming the lively San Miguel Food Market and winery hopping in the nearby Las Ventas region. Learn more

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Itinerary #3: Coastal Spain & Southern Italy Trip: Barcelona, Costa Brava, Amalfi Coast & Naples

Perfect for ocean lovers, this 10-day itinerary features idyllic coastal hikes, kayaking excursions, peninsula tours, and long afternoons hopping between charming cliffside villages. There's no shortage of cultural excursions, either, as you admire Barcelona's famed Antoni Gaudí architecture, meander Capri's Gardens of Augustus, and roam Naples' history-laden streets. 

Visit towns like Cadaqués along Spain's sparkling Costa Brava
Visit towns like Cadaqués along Spain's sparkling Costa Brava
Day Highlights Overnight
Day 1 Arrive in Barcelona (Spain), Guided Tapas Walking Tour Barcelona
Day 2 Tour the Gaudí Masterpieces of La Sagrada Família & Park Güell Barcelona
Day 3 Drive to the Costa Brava, Free Afternoon to Explore Costa Brava
Day 4 Coastal Hike, Kayaking & Lagoon Dipping in the Costa Brava Costa Brava
Day 5 Excursion to Vic, Besalú & the Costa Brava's Medieval Towns Costa Brava
Day 6 Fly to Naples (Italy), Transfer to the Amalfi Coast, Sunset Cruise Along the Bay Amalfi Coast
Day 7 Amalfi Coast Tour by Vespa Amalfi Coast
Day 8 Day Trip to Capri & Anacapri Amalfi Coast
Day 9 Transfer to Naples via Pompeii, Free Afternoon to Explore  Naples
Day 10 Optional Street Food Tour, Depart Naples  

Kick off your sun-kissed adventure in the coastal city of Barcelona, where you'll shrug off jet lag while stumbling upon lesser-known tapas spots in the Gothic Quarter and admiring Antoni Gaudí's architecture on a guided walking tour. Then, repack your bags and transfer south to the Costa Brava, a superb stretch of Mediterranean coastline renowned for its charming small towns, rugged cliffs, and inviting beaches. A three-day stay ensures you have plenty of time to sip an aperitif in the quaint fishing village of Llafranc, hike to Sant Pol de S'Agaró for a kayaking excursion, and explore the region's medieval towns.

On Day 6, catch a flight to Naples, Italy, transfer to the vibrant Amalfi Coast, and set out on a memorable sunset cruise on the Tyrrhenian Sea. The following day features a Sorrentine Peninsula tour from the back of a Vespa, complete with time to meander through cobbled backstreets in Positano and Amalfi. Then, dedicate a day to exploring the island of Capri, with its manicured Gardens of Augustus, before returning to Naples. On the way, stop at Pompeii to witness the ancient city perfectly preserved by volcanic ash and wrap up your trip by sampling Neapolitan street food. Learn more

Itinerary #4: City Culture & Outdoor Adventure in Spain & Italy

Active travelers eager to discover the mountainous landscapes of Spain and Italy will find this outdoor adventure itinerary the perfect fit. The main highlight is a three-day hike in the Italian Dolomites, where you'll sleep in tucked-away mountain huts and trek through lush valleys and past thundering rivers. Other notable excursions include a hike in the foothills of the Pyrenees mountains, time to explore around the Monastery of Montserrat, and city tours in Barcelona and Venice.

Take a day trip to Monserrat from Barcelona for hiking and cava tasting
Take a day trip to Monserrat from Barcelona for hiking and cava tasting
Day Highlights Overnight
Day 1 Arrive in Barcelona (Spain), Tapas Tour Barcelona
Day 2 Barcelona Bike Tour, Visit Sagrada Familia Barcelona
Day 3 Day Trip to Rupit, Group Hike Barcelona
Day 4 Day Trip to Montserrat & Cava Wine Tasting Barcelona
Day 5 Fly to Venice (Italy), Food Tour Venice
Day 6 Transfer to the Dolomites, Trekking Day 1 Dolomites
Day 7 Dolomites Trekking Day 2 Dolomites
Day 8 Dolomites Trekking Day 3, Transfer to Lake Garda Dolomites
Day 9 Desenzano & Sirmione Tour, Optional Hot Springs Lake Garda
Day 10 Optional Wine Tasting, Transfer to Milan, Depart  

Before delving into the many active excursions featured on the itinerary, your adventure begins with a compelling food tour through Barcelona's Gothic Quarter. Then, hop on two wheels and pedal between the Barcelona Cathedral and Barceloneta Beach, and set aside time to tour La Sagrada Família. Next, warm up your hiking muscles with a scenic trek in the foothills of the Pyrenees, followed by a day walking around the iconic Monastery of Montserrat and learning the craft of cava-making in the Penedès wine region. On the morning of Day 5, it's time to pack your bags and board a flight bound for Venice, Italy. 

In Venice, enlist the help of an expert local guide to better discover the charm of the Grand Canal and the bustling Rialto Market. Then, wake early the following morning, transfer out of the city, and don your hiking boots for a bucket-list three-day trek in the Italian Dolomites. Starting from the foot of the Ortler Alps, you'll hike under Stelvio National Park's towering peaks, trek through the grassy slopes of Saent Valley, and take in the cascading Saent Falls. Afterward, enjoy a relaxing end to your travels while basking in one of Lake Garda's many thermal springs and sipping wine in the Valpolicella region. Learn more

Itinerary #5: Off the Beaten Path Road Trip in Spain & Italy

Immerse yourself in the lesser-known treasures of Spain and Italy on this road trip through Madrid, León, Bilbao, Rome, and more. Ideal for seasoned travelers seeking new experiences, this itinerary includes a rooftop tour of Madrid, visits to out-of-the-way historic towns, and a gourmet pintxos tour in Bilbao. Other fascinating highlights include a boat tour on Lake Bolsena and wine tasting in Orvieto, ensuring a delightful blend of culture, history, and gastronomy.

Drive to the UNESCO-listed city of Burgos, a stop along the Camino de Santiago pilgrimage route
Drive to the UNESCO-listed city of Burgos, a stop along the Camino de Santiago pilgrimage route
Day Highlights Overnight
Day 1 Arrive in Madrid (Spain), Rooftops Tour Madrid
Day 2 Pick Up Rental Car, Drive to León, Walking Tour León
Day 3 Drive to Burgos via Atapuerca, Explore Burgos
Day 4 Drive to Bilbao via Vitoria-Gasteiz, Pintxos Tour Bilbao
Day 5 Fly to Rome (Italy), Highlights Tour Rome
Day 6 Pick Up Rental Car, Drive to Viterbo via Calcata Viterbo
Day 7 Drive to Bolsena via Civita di Bagnoregio, Explore Bolsena
Day 8 Lake Bolsena Boat Tour Bolsena
Day 9 Drive to Orvieto, Tour & Wine Tasting Orvieto
Day 10 Drive to Rome, Depart  

Your adventure begins in Madrid, where you'll shrug off any travel fatigue during an exclusive rooftop tour and collect your rental car. Hit the road to León next and get to know the stories behind the city's well-preserved Roman Walls and the grand Catedral de León, thanks to the help of a local guide. Continue your drive east to Burgos the following day, stopping in the UNESCO-listed city of Atapuerca to ponder archaeological finds dating back 1.2 million years. Then, dedicate an evening to sampling Bilbao's mouthwatering pintxos before dropping off your rental car and catching a flight to Italy.

Arriving in Rome, you'll dive straight into exploring, with a guided highlights tour on the agenda. Next, pick up another rental car and begin your Italian road trip, starting with a drive to Viterbo for an afternoon dedicated to roaming the city's well-preserved medieval quarter. Then, it's back in the car for a drive to Bolsena, Europe's largest volcanic lake, where you'll spend a leisurely day boating past charming villages dotted along the lakeshore. However, before you know it, you'll be sipping wine in Orvieto and returning your rental car to Rome, ready for your onward journey. Learn more

More Great 10-Day Spain Itineraries

Looking for more inspiration for your trip to Spain? Check out these other 10-day Spain itineraries, with outdoor adventures, cultural trips, and best-of tours to hit the highlights.


Map of 10 Days in Spain & Italy - 5 Unique Itinerary Ideas
Map of 10 Days in Spain & Italy - 5 Unique Itinerary Ideas