Consider yourself lucky if you have two weeks to spend in Bolivia: it's enough time to see many of the country's landscapes and cultural attractions. You could choose to focus on the Bolivian highlands, enjoying the colonial charm of Sucre, boating around Lake Titicaca, and driving through the one-of-a-kind Uyuni Salt Flats. Or you could center your trip around exploring indigenous cultures, opting for an itinerary that takes you to the farthest reaches of the Amazon and the Andes. Another option is to combine 10 days in Bolivia with a few more in Chile's Atacama Desert.

Itinerary #1: Highlights of Bolivia & Chile 

Explore the cultural highlights and beautiful landscapes of Bolivia and Chile on this wide-ranging 14-day trip around both countries that features experiences in the Uyuni Salt Flats, Lake Titicaca, and the Atacama Desert.

A woman walking on Isla del Sol
Day Highlights Overnight
Day 1 Arrive in Santa Cruz de la Sierra Santa Cruz de la Sierra
Day 2 Day Trip to Biocentro Güembé Santa Cruz de la Sierra
Day 3 Visit the Historic Village of Samaipata Samaipata
Day 4 Trek through Amboró National Forest Samaipata
Day 5 Discover La Paz on a City Tour La Paz
Day 6 Boat Around Lake Titicaca  Isla del Sol
Day 7 Explore the Island of the Sun  La Paz
Day 8 Free Day in La Paz La Paz
Day 9 Tour the Uyuni Salt Flats Colchani
Day 10 Spot Wildlife in the Eduardo Avaroa Andean Fauna National Reserve Siloli
Day 11 Transfer to the Atacama Desert San Pedro de Atacama
Day 12 Visit the Valley of the Moon & the Valley of Death San Pedro de Atacama
Day 13 See the Tatio Geysers & Machuca Village San Pedro de Atacama
Day 14 Depart Chile   

Welcome to Bolivia! Start the adventure in Santa Cruz de la Sierra. You'll go on a day trip to Biocentro Güembé to see macaws, toucans, peacocks, and other tropical birds, then go trekking through the green hills of Amboró National Forest. Continue to the high-altitude capital city of La Paz, which you'll get to know during a guided city tour. The trip takes you to Lake Titicaca next to enjoy the unique island setting of Isla del Sol and learn about indigenous traditions.

Back-track to La Paz midway through the itinerary. Go on a cable car ride or a food tour of the city before heading to the great white expanse of the Uyuni Salt Flats. Look for native wildlife in the Eduardo Avaroa Andean Fauna National Reserve before crossing the border to Chile. You'll spend the last few days of the trip exploring the Atacama Desert. Highlights include sandboarding on massive sand dunes, visiting the Valley of the Moon and the Valley of Death, and seeing the breathtaking Tatio Geysers at dawn. Learn more

Itinerary #2: Adventure in the Bolivian Highlands 

Venture to the highlands of Bolivia on this two-week journey through the country's rugged landscapes, from colorful lagoons and Lake Titicaca to the salt flats of Uyuni and the famed silver mine of Potosí.

A striking view of Potosí, Bolivia
Day Highlights Overnight
Day 1 Arrive in Sucre Sucre
Day 2 Explore the Ciudad Blanca of Sucre Sucre
Day 3 Day Trip to the Maragua Crater Sucre
Day 4 Transfer to Potosí & Visit the Casa de Moneda Potosí
Day 5 Sightsee in Potosí & Transfer to Tupiza Tupiza
Day 6 See Ghost Cities & Super Volcanoes  Quetena Chico
Day 7 Discover Lakes, Geysers & Hot Springs  Laguna Colorada
Day 8 Spot Flamingos in the Wild at Laguna Colorada San Juan
Day 9 Explore the Salar de Uyuni & Isla Incahuasi  Overnight Bus
Day 10 Free Day in La Paz La Paz
Day 11 Travel to Lake Titicaca Isla del Sol
Day 12 Tour Isla del Sol Isla de la Luna
Day 13 Hike on Isla de la Luna  La Paz
Day 14 Depart La Paz   

Begin the trip in the colonial gem of Sucre. You'll base yourself here for a few days, touring the city's markets and museums, then day-tripping to the Maragua Crater, where you'll learn about the development of weaving and textile traditions in the crater's villages. Transfer to Potosí next, where you'll visit the Casa de Moneda, one of the best museums in South America. You'll also descend deep into the Cerro Rico mine to learn about the history of Spanish mining in the region.

Stop to see ghost towns, geysers, lakes, and hot springs on the way to the red-hued Laguna Colorada, home to a large number of flamingos. On day nine, tour the Uyuni Salt Flats and the otherworldly Isla Incahuasi before taking an overnight bus back to La Paz. The rest of the trip is devoted to exploring Lake Titicaca and its islands, including hiking on Isla de la Luna and meeting locals to learn about traditional fishing, cooking, and crafts on Isla del Sol. You'll have one last night in La Paz before flying out. Learn more

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Itinerary #3: Trekking in the Bolivian Andes & Amazon 

Perfect for outdoorsy travelers interested in indigenous cultures, this active adventure through Bolivia features canoeing in the Amazon, hiking in the Andes, and boating around Lake Titicaca, learning about ancestral traditions on the lake's islands. 

Floating structures on Lake Titicaca
Day Highlights Overnight
Day 1 Arrive in La Paz La Paz
Day 2 Walking Tour of El Alto La Paz
Day 3 Explore Lake Titicaca & the Island of the Sun Isla del Sol
Day 4 Visit the Community of Santiago de Okola Santiago de Okola
Day 5 Tour Apolobamba National Park Charazani
Day 6 See the Chullpa Pata Citadel  Chari
Day 7 Trek to Charazani  La Paz
Day 8 Free Day in La Paz La Paz
Day 9 Go on a Canoeing & Hiking Expedition Rurrenabaque
Day 10 Birdwatch & Raft in Madidi National Park Madidi National Park
Day 11 River Safari in Yacuma Forest Preserve Santa Rosa Beni
Day 12 Hike in the Jungle & Return to La Paz La Paz
Day 13 Sightsee & Shop in La Paz La Paz
Day 14 Depart La Paz   

Kick off the journey in La Paz. You'll adjust to the altitude and go on a walking tour in the adjacent city of El Alto before moving on to explore Lake Titicaca. Sleep under the stars on an island before visiting the agritourism project in the community of Santiago de Okola, where you'll have the chance to interact with members of the local indigenous group. Then it's onward to Apolobamba National Park to enjoy a trekking day and an Andean lunch, stopping at several tiny villages along the way.

Continue the hike to Charazani before heading back to the big city to do some more sightseeing in La Paz. The following day, you'll travel to the Amazon, where canoeing and hiking adventures await. Go rafting and birdwatching in Madidi National Park, followed by a once-in-a-lifetime river safari in Yacuma Forest— it's a fantastic opportunity to see caimans, capybaras, turtles, and the unique freshwater Amazonian pink river dolphin. Head back to La Paz to enjoy shopping, riding cable cars, and sampling Bolivian cuisine. The trip ends here, where it started. Learn more

Itinerary #4: Highlights of Peru and Bolivia

See the best of Peru and Bolivia on this two-week journey through both countries, including stops at Lake Titicaca, the salt flats of Uyuni, Machu Picchu, and the Sacred Valley.

Exploring the salt flats of Uyuni
Day Highlights Overnight
Day 1 Arrive in Lima & Sightsee Lima
Day 2 Transfer to Cusco & Explore Pisac Sacred Valley
Day 3 Tour the Ruins of Machu Picchu  Sacred Valley
Day 4 See the Ollantaytambo Fortress & Transfer to Cusco Cusco
Day 5 Hike Around Rainbow Mountain & the Red Valley Cusco
Day 6 Enjoy a Scenic Drive from Cusco to Puno Puno
Day 7 Sail to the Uros Floating Islands & Taquile Puno
Day 8 Fly from Puno to La Paz via Lima La Paz
Day 9 Discover the Ruins of Tiwanaku  La Paz
Day 10 Travel from La Paz to Uyuni Uyuni
Day 11 Explore the Uyuni Salt Flats Uyuni
Day 12 Visit the Salt-Harvesting Capital of Colchani Uyuni
Day 13 Dine, Sightsee & Shop in La Paz La Paz
Day 14 Depart La Paz   

Welcome to Peru! You'll arrive in Lima and spend the afternoon strolling around the oceanfront neighborhood of Miraflores. Then transfer to Cusco and start exploring the Sacred Valley, heading to the ruins of Machu Picchu on day three. Visit the fortress of Ollantaytambo and go hiking around vibrant Rainbow Mountain and the Red Valley. Then spend the evening relaxing in Cusco, shopping for handicrafts, and sampling Peruvian cuisine. After the next day's scenic drive to Puno, you'll explore Lake Titicaca, boating to the floating islands of Uros and having lunch on Taquile Island.

The second week of the trip takes you to Bolivia. Land in La Paz and side-trip to the ancient settlement of Tiwanaku. Then you'll be off for a three-day excursion to the salt flats of Uyuni. Go on a Jeep tour through the great white expanse, catching unforgettable sunsets each evening. You'll visit the old salt-harvesting town of Colchani to learn about the region's interesting history before heading back to La Paz for a day of sightseeing and shopping before the adventure is over. Learn more

More Great Bolivia Itineraries

Looking for more inspiration for your trip to Bolivia? Check out these other Bolivia itineraries, with outdoor adventures, cultural trips, and best-of tours to hit the highlights. 


Map of 2 Weeks in Bolivia - 4 Unique Itinerary Ideas
Map of 2 Weeks in Bolivia - 4 Unique Itinerary Ideas