Perfect for travelers looking to explore Bolivia's best cities and UNESCO-designated natural wonders, this 10-day itinerary combines cultural experiences with jaw-dropping desert vistas. You'll start in the colonial gems of Santa Cruz de la Sierra and Sucre before continuing on to a lush hacienda that dates back to the 1550s. Then, set off for the protected Eduardo Avaroa Andean Fauna National Reserve that's home to colorful lagoons, the magical Uyuni Salt Flats, and Siloli Desert. 

Highlights

  • Take a walking tour of Sucre, the charming former capital
  • See the famous Uyuni Salt Flats & Incahuasi Island
  • Spot wild flamingoes in the Eduardo Avaroa Andean Fauna reserve
  • Tour UNESCO World Heritage Site of Tiwanaku
  • Soar above La Paz on a cable car tour of the city

Brief Itinerary

Day Highlights Overnight
Day 1 Arrive in Santa Cruz de la Sierra Santa Cruz de la Sierra
Day 2 Tour of Sucre Sucre
Day 3 Free Morning in Sucre - Transfer to Cayara Cayara
Day 4 Cayara Hotel Museum - Transfer to Colchani Colchani
Day 5 Explore the Uyuni Salt Flats Colchani
Day 6 Eduardo Avaroa Andean Fauna Reserve Siloli
Day 7 Thermal Baths - Flight to La Paz La Paz
Day 8 Cable Car Tour of La Paz La Paz
Day 9 Day-Trip to Tiwanaku & Lake Titicaca La Paz
Day 10 Depart La Paz  

Detailed Itinerary

Day 1: Arrive in Santa Cruz de la Sierra

Jesuit church in Santa Cruz de la Sierra
Jesuit church in Santa Cruz de la Sierra

Welcome to Bolivia! Today, you’ll arrive in Santa Cruz de la Sierra, a lowland city of 1.5 million inhabitants living at a staggering 1,312 feet (400 meters) above sea level with an average daily high temperature of 86°F. You will be picked up at the Viru Viru International Airport (VVI) and transferred to your accommodation in Santa Cruz de la Sierra.

You can relax in the hotel and use the pool, or have a cool drink and settle in before this afternoon’s city tour. After having a lunch of your choosing, your bilingual guide will take you on a three-hour tour around the city center. Afterward, you'll have time to rest before tomorrow's activities.

Day 2: Tour of Sucre

View from a rooftop in Sucre
View from a rooftop in Sucre

This morning, a driver will pick you up at your hotel and take you to Sucre, the constitutional capital of Bolivia and the place where the first resistance movements seeking to overthrow the Spanish colonial government began. 

On your tour of the city, you will learn about the city's role not only in Bolivian history but in the history of Latin America. First, you will visit La Casa de la Libertad, where Bolivia's proclamation of independence from Spain was signed. You will also visit the ASUR Museum of Indigenous Art, a "living" museum with textiles from the southern Andes, art by indigenous groups from the region, and local artists working in the city. 

After your museum visit, you'll have the rest of the evening free to continue exploring Sucre or stay at your hotel.

Day 3: Free Morning in Sucre - Transfer to Cayara

Bolivian textiles and blankets in a market
Bolivian textiles at a market in Sucre

You will have the morning free to relax at your hotel, explore Sucre on your own, or book an optional activity. We recommend a guided visit to the Cal Orcko Footprints, the largest collection of dinosaur tracks found in the world.

In the afternoon, a private driver will pick you up and take you on a three-hour drive to Cayara. Once you arrive, you will check in and have the evening free to enjoy the hacienda.

Day 4: Cayara Hotel Museum - Transfer to Colchani

Cayara Hotel-Museum near Potosi
Inside the Cayara Hotel Museum

You'll start your day with a guided visit to the Cayara Hotel Museum, a restored colonial hacienda that dates back to 1557. preserves many of the practices of colonial life and farming. The museum hosts a collection of notable paintings and pieces of furniture along with two impressive libraries. Military history buffs will be especially interested in the museum's collection of armor, muskets, and sabers that were used during the War of Independence.

After your tour of the house and the surrounding grounds, a driver will take you to Potosí for your walking tour of the city with a local guide and lunch.

In the late afternoon, your driver will take you on a three-hour ride to the salt-harvesting village of Colchani, the gateway of the Uyuni Salt Flats, where you'll stay for the night.

Day 5: Explore the Uyuni Salt Flats

View of the Uyuni Salt flats
View of the Uyuni Salt flats

Today begins with a short visit to the famed (and rusting) Train Cemetery of Uyuni. Then, a guide will take you to the great Uyuni Salt Flats, and you will visit the enigmatic Incahuasi Island, which is covered in enormous cacti. You can enjoy the sunset over the flats before a driver returns you to Colchani for the night.

Day 6: Eduardo Avaroa Andean Fauna National Reserve

The Red Lagoon
The Red Lagoon

After breakfast, you will continue our highland adventure with an eight to 10-hour drive through the high desert to the southern Altiplano.

You will see lunar-like landscapes, volcanos, deserts, and colorful lagoons once you reach the Eduardo Avaroa Andean Fauna National Reserve. As the country's most visited protected area, the reserve boasts volcanos, deserts, colorful lagoons, and Andean wildlife like pink flamingos and llamas.

After a short walk around the reserve, you'll have lunch next to one of the region’s many-colored lagoons before continuing on to Siloli Desert. Once you reach the desert, you can see the famous Stone Tree, which was formed by years of wind erosion.

Your excursion will end with a visit to the Red Lagoon (Laguna Colorada) before your driver takes you to your accommodation in Siloli for a well-earned rest.

Day 7: Thermal Baths - Flight to La Paz

The geysers impress no matter what time or season you visit
Steam from the thermal pools in Siloli

After an early breakfast, you'll be able to take a relaxing dip in the thermal pools nearby. Once you feel refreshed, you'll continue your journey with another eight to 10-hour drive.

You'll turn back toward the northeast and travel through more of the Siloli Desert (also known as the Dali Desert), passing by the Green Lagoon along the way. You'll reach Uyuni Airport (UYU) in the afternoon and board your flight to La Paz.

Once you land in La Paz, a driver will be waiting to transfer you to your accommodation.

Day 8: Cable Car Tour of La Paz

Mi Teleferico cable car above the city of La Paz

After breakfast, you will explore the city via the city's new cable car system. Established in 2017, the Mi Teleférico transit system boasts a network of 10 lines that criss-cross the city. Your full-day tour will take you on six different lines—from the adjacent city of El Alto to La Paz's bohemian neighborhood of Sopocachi with modern buildings, bustling squares, and public parks. The tour will end with a stroll along colonial Jaen Street with its five small museums and plenty of history.

In the afternoon, you'll be returned to your hotel where you'll have the rest of the evening free.

Day 9: Day-Trip to Tiwanaku & Lake Titicaca

Tranquility on Lake Titicaca
Tranquility on Lake Titicaca

This morning, a guide will take you to the ruined city of Tiwanaku, a UNESCO World Heritage Site. You will see the main temples, some of which are still under excavation, including the Pyramid of Akapana, Kalasasaya and Puma Punku, and the inspiring Gateways to the Sun and Moon

In addition to the traditional examples of Tiwanaku's architecture, giant monoliths and figurative representations are scattered throughout the archeological complex. Huge stone blocks weighing as much as 45 tons each are placed with such precision that not a single gap exists between them. Intricate sculptures of both the ancient people and their gods can also be seen on-site.

The Tiwanaku culture was tightly linked to Lake Titicaca, and the second half of today's tour blends the past with the present, making for a wonderful excursion through time and across landscapes. After lunch, you will set off for Huatajata, a small farming village on the shore of Titicaca where we’ll visit the interpretation center. You will learn about the boat-building traditions of the Totora before taking one of the reed boats out for a spin. 

After your day on the lake, your driver will return you to your hotel in La Paz. You'll have the rest of the evening free to explore La Paz, purchase your final souvenirs, or have a nice meal.

Day 10: Depart La Paz

View of the Andes mountains outside La Paz
View of the Andes mountains outside La Paz

It's time to say goodbye to Bolivia! After you have breakfast and spend a final morning enjoying La Paz, a driver will pick you up at your hotel. You'll be taken to the airport to catch your flight.

Map

Map of Bolivia Highlights: La Paz, Sucre, Uyuni Salt Flats - 10 Days
Map of Bolivia Highlights: La Paz, Sucre, Uyuni Salt Flats - 10 Days