South America's Hidden Treasures: Northern Argentina, Buenos Aires & Uruguay - 14 Days

Highlights

• Explore the colonial cities and colorful deserts of northern Argentina
• Go on wine tours and relax in hot springs around Córdoba
• Stroll the wide boulevards of Buenos Aires and enjoy dinner and a tango show
• Cruise the Río Plata and hop over to Uruguay for tours of Colonia and Montevideo

Brief Itinerary

Detailed Itinerary

Day 1: Arrive in Salta (Argentina), Night at the Peñas

Welcome to Argentina! Many know South America's second-largest country for its dazzling capital of Buenos Aires, but it's also filled with unspoiled natural wonders, from the wilds of Patagonia to the northern deserts. This two-week adventure kicks off in the north when, after catching a connecting flight in Buenos Aires, you'll travel two hours to Salta.

Officially founded in 1582 in the mountains of northwest Argentina, this metropolis is known for its well-preserved Spanish-colonial architecture. In particular, the historic city center is defined by landmarks like the 19th-century Salta Cathedral, which overlooks Plaza 9 de Julio, the main square. Upon arrival at the airport, a driver will pick you up and drive you to your hotel.

After some time to settle in, you'll head out in the evening for a snack and a drink at one of the city's famous peñas. These historic saloons and restaurants have been around since at least the 18th century, and locals still flock to them to enjoy a few drinks and live Argentine folk music.

Day 2: Day Trip to Cafayate

Rise and shine! This morning, you'll hit the road on a day trip to explore the surrounding mountain and desert landscapes. Meet your driver early and leave Salta, heading south on Route 68 for about three hours until you reach the town of Cafayate. To say this is a scenic drive would be an understatement. Along the way, you'll pass some of northern Argentina's most beautiful landmarks.

One highlight is the Quebrada de las Conchas, a deep valley of red canyons characterized by intense colors and unusual rock formations. The names of these geological wonders reflect their characteristics, like the Devil's Throat, the Amphitheater, the Frog, and the Obelisk. Feel free to stop wherever you like to take a walk around and snap photos.

Then, continue to Cafayate. This tourist town is nestled in the Calchaquí Valley of Salta province and is renowned for its vineyards. In fact, this is the premier wine-growing region of northern Argentina, famous for producing torrontés, an aromatic white wine. You can sample a glass or two of this prized varietal when you break for lunch at a local restaurant. After a leisurely meal, you'll transfer back to Salta via Quebrada de las Conchas and the Lerma Valley, filled with otherworldly landscapes.

Day 3: Transfer to Jujuy, City Tour

After breakfast, your driver will pick you up for the two-hour ride north to San Salvador de Jujuy (known simply as "Jujuy"). Capital of the province of the same name, this city is the gateway to many wonders of Argentina's far north. These include colorful Indigenous towns, vast salt flats, and the Puna de Atacama, a remote high-altitude desert. Upon arrival in the city, your driver will drop you off at your hotel.

Just like in Salta, there are many fascinating historical landmarks to see in Jujuy. So, after dropping off your bags, you'll meet a local guide and head out on a tour that begins around the Plaza España, located in the historic center. Highlights you'll stop at during the tour include the 18th-century Cathedral Church, with its pulpit laminated in gold; the Cabildo de Jujuy (Government House), which dates to the 16th century; and the impressive Basilica Menor San Francisco, an 18th-century church with a Baroque facade, intricate carvings, and decorative motifs.

Day 4: Day Trip to Hot Springs & Lagoons

It's another day to enjoy northern Argentina's fabulous countryside. Depart your hotel in the morning, following the Río Grande northwest out of Salta, passing colorful villages as you go. You'll stop in one such town, Yala, to stretch your legs. While here, enjoy prime views of the surrounding Los Nogales region, with its citrus fields and rolling hills backed by towering Andes peaks.

Then, follow a mountain road to Potreros de Yala Provincial Park. This protected area encompasses diverse ecosystems, like high-altitude cloud forests, montane woodlands, and lush valleys, making it a popular spot for outdoor adventures. Once here, you'll embark on a brisk hike to Laguna de Yala, a glassy lake surrounded by lush vegetation that is home to abundant birdlife. Spend a few minutes relaxing on the lakeshore, where you can spot waterbirds like egrets and herons skimming the surface. 

The journey continues until you reach an epic viewpoint adjacent to thermal springs. There, you'll treat yourself to a refreshing dip in these natural pools or opt for a more exclusive treatment at the on-site spa. Afterward, you'll return to the car and pass by more charming towns on your way back to Jujuy.

Day 5: Transfer to Córdoba, Optional Activities

Say goodbye to northern Argentina as you transfer to the airport this morning and board a 1.5-hour flight south to Córdoba. Located in the center of the country and surrounded by the towering Sierras de Córdoba, the city is known for its colonial architecture, surrounding wine country, and lively festivals. At the airport, a driver will pick you up and transfer you to your hotel.

Once you settle in, head out to explore at your own pace. A great place to start is in the UNESCO-listed Jesuit Block, which holds some of the most beautiful buildings in the city. Wander through the charming streets of the Güemes neighborhood, stopping at trendy boutiques, eclectic cafés, and street murals. For outdoor relaxation, head to Sarmiento Park, an expansive green space ideal for an afternoon of picnicking, paddle boating on the lake, or exploring the rose garden.

Day 6: Calamuchita Wine Tour & Day Trip to General Villa Belgrano

Hope you're thirsty because you're off on a day trip to the Calamuchita Valley, the most famous wine region in this part of the country. It's home to several boutique vineyards that produce an array of varietals, including cabernet sauvignon, syrah, torrontés, and Argentina's most famous grape, malbec.

On this guided tour, you'll wind your way through the green valley to the mountain town of La Cumbrecita. Forests and Alpine views abound in this pedestrian-only village, full of historic buildings and cafés. Continue on to Villa General Belgrano, a German town known for its alpine-style architecture, beer gardens, and Oktoberfest celebration, which is one of the largest in Argentina.

On your way back to Córdoba, you'll stop at several famous wineries along the Calamuchita Wine Road. Many of these wine estates are family-run, and you'll enjoy the fruits of their terroir during visits to the tasting rooms. At the end of the day, you'll return to your hotel.

Day 7: Horseback Riding at Candonga Estancia

In the morning, set off with your driver to Candonga Estancia, an authentic ranch near the countryside town of El Manzano. Here, you'll spend the day learning about the life of a gaúcho (Argentine cowboy) and the basics of horseback riding. Once you're comfortable on your horse, hop in the saddle and trot along with your guide on the paths and mountain roads around the ranch.

Enjoy the beautiful rural scenery as you ride, occasionally letting your horse loose for an exhilarating gallop. There will be a stop for lunch at a natural pool, ideal for swimming. After eating, continue the ride into the later afternoon. There will be another break for a snack before returning to the estancia and driving back to Córdoba. 

Day 8: Fly to Buenos Aires, Dinner & Tango at Café De Los Angelitos

City life beckons, as this morning, you'll transfer to the airport and board a plane for the 1.5-hour flight south to Buenos Aires. This grand metropolis is nicknamed the "Paris of the South" due to its Euro-centric roots, wide boulevards, leafy parks, and neoclassical and Baroque architecture. In this city, you can stroll cobbled streets while plaintive notes of tango reverberate from nearby milongas (music halls). 

After checking into your hotel, you'll be treated to a live performance of Argentina's flagship musical styling. A driver will pick you up in the evening for the ride to Café de los Angelitos. Located in the historic Balvanera neighborhood, it was founded in 1890 as a dirt-floor saloon and meeting point for swaggering gaúchos and malandras (scoundrels). It was the perfect venue to host the burgeoning dance-musical styling known as tango, which has its roots in the capital's rough-and-tumble ports in the late 19th century.

When you arrive, you'll be led to your table, where you'll be served classic Argentine dishes paired with robust wine. Then, as the lights dim, the performers will take the stage and entertain the audience with a dance that tells stories of the romance, violence, and passion that once defined Buenos Aires' tenements—and still echo through the city today. At the end of the evening, you'll return to your hotel.

Day 9: Paraná Delta Full-Day Tour

Buenos Aires sits on the Río de la Plata, near the Paraná Delta—that's why residents of the city are known as Porteños (People of the Port). You'll have the whole day to explore this riverine region when, in the morning, you'll transfer to the north of the city and Puerto San Fernando. There, you'll board a traditional wooden flatboat for a ride around the scenic Paraná Delta, a waterway formed by several islands known as the Islas del Paraná.

Then, you'll set sail, cruising the tributaries and streams of the Delta, enjoying views of the peaceful greenery and waterfront villages with their grand manor estates. The boat will drop anchor at lunchtime, and you'll enjoy a delicious meal onboard. Afterward, there will be time for a swim, listening to music, or just relaxing and admiring the views. You'll return to the port this afternoon and then transfer to your hotel at the end of the day.

Day 10: Day Trip to San Antonio de Areco & Estancia El Ombú 

Get ready for a full day on the prairie to experience Argentina's famous frontier culture. In the morning, you'll meet your driver for the 72-mile (117 km) transfer northwest from Buenos Aires to the Pampas flatlands and San Antonio de Areco. This bucolic town is the heart of Argentina's gaúcho culture and even today retains its equestrian and silversmith traditions. It's also rich with folk history, inspiring Argentine author José Hernández's epic poem "Martín Fierro." The ballad recounts the exploits of its fictional hero as he endures life on the frontier. 

Your destination is right outside San Antonio, at Estancia El Ombú. This colonial-style mansion was built in 1880 and sits on expansive green grounds, offering visitors an authentic Argentine countryside experience. Once here, there are various options for activities: you can go horseback riding, hiking, or sightseeing in an old-fashioned, horse-drawn carriage. The estancia is also a working farm, and you can observe typical ranch-style activities such as herding animals, branding cattle, and milking cows.

A highlight of the day is sitting down to a traditional asado (Argentine barbecue). Enjoy grilled meat and empanadas paired with Argentine wine while being entertained by horse shows and traditional folk dancing. Afterward, you'll transfer back to Buenos Aires and your hotel.

Day 11: Ferry to Colonia del Sacramento (Uruguay), Walking Tour & Maté

Say adiós to Argentina and hop on a one-hour ferry to the beautiful city of Colonia del Sacramento in Uruguay. The entire town is a UNESCO Heritage Site, and the streets are packed with history. After you arrive, join a local guide to tour the cobblestone lanes and discover sites such as the Portón de Campo (Old City Gate) and the pretty, historic avenue known as Calle de Los Suspiros (Street of Sighs). 

During the tour, you'll have the opportunity to taste maté, a traditional tea made from the leaves of the yerba maté plant. The tea is prepared in an ancient ritual practiced in the Paraña region of Uruguay, Argentina, and Paraguay for generations. A local maté expert will teach you the basics of making tea and provide background on the drink's history. Sample different varieties and taste regional pastries to refuel during your walk, then return to the hotel, where you'll have the rest of the afternoon free. 

Day 12: Tour Jesuit Ruins & Wine Tasting in Carmelo

Take a day trip to the birthplace of wine in Uruguay at La Caléra de las Huérfanas National Monument, a former Jesuit mission-turned vineyard. Along with your guide, you'll explore ruins and well-kept grounds that date back to 1741. After learning about this vital historical landmark, you'll travel an hour up the coast to the town of Carmelo, where you'll enjoy several wine tastings. 

Begin at the Bodega Cordano, a family-run winery dating back centuries. Enjoy a tour of the vineyards and production areas with the owners and a tasting of several of their signature wines. You can also buy wine and souvenirs at the on-site Almacén de la Capilla, a vintage grocery store founded in 1855. 

Your next stop will be the Bodega El Legado, a boutique family-owned winery. Your visit includes a guided tour through the vineyards, wine cellar, and production area, followed by a tasting and lunch. Enjoy the three wines accompanied by a cheese and olive plate, then sit down for a traditional asado (Uruguay does barbecue just like Argentina). After the tours, you'll travel back down the coast to Colonia. 

Day 13: Colonia Walking Tour, Transfer to Montevideo & Coastal Bike Ride

Spend the morning wandering the cobbled streets of Colonia, purchasing handcrafted souvenirs, and enjoying the river views. Around midday, board a bus for the two-hour ride south to Montevideo. Uruguay's capital is a beguiling metropolis similar to Buenos Aires in terms of history, culture, cuisine, and architecture. Though smaller than its Argentine counterpart, Montevideo enjoys a much more scenic locale on the estuary of the Río Plata. 

A driver will pick you up at the terminal and transfer you to your hotel in the city. With only half a day left, you've got a lot of ground to cover if you want to see the sights. Lucky for you, you'll meet a local guide for a three-hour bike ride around the waterfront. It begins near the river at Mercado del Puerto, a municipal market dating to the 19th century that serves up some of the best-grilled meats in the city.

After lunch, you'll hop on your bike for a leisurely ride down the Rambla, the coastal avenue that separates Montevideo from the shores of the Atlantic. It's a 12-mile (18 km) scenic ride, and there will be plenty of stops to snap photos of city landmarks and the beautiful coast. After the tour, you'll return to your hotel and can enjoy one last night out in the big city before departing tomorrow.

Day 14: Depart Montevideo

It's been a wild two weeks, and you've covered a lot of ground. Now, it's time to pack up the memories and depart. Enjoy one more breakfast at your hotel before meeting your driver for the ride to the airport in Montevideo, where your flight home awaits. Safe travels!

More Great Argentina Itineraries